منابع مشابه
Pathological potential of astroglia.
The pathological potential of glial cells was recognized already by Rudolf Virchow, Santiago Ramon y Cajal and Pio Del Rio-Ortega. Many functions and roles performed by astroglia in the healthy brain determine their involvement in brain diseases; as indeed any kind of brain insult does affect astrocytes, and their performance in pathological conditions, to a very large extent, determines the su...
متن کاملMemory Formation Shaped by Astroglia
Astrocytes, the most heterogeneous glial cells in the central nervous system (CNS), execute a multitude of homeostatic functions and contribute to memory formation. Consolidation of synaptic and systemic memory is a prolonged process and hours are required to form long-term memory. In the past, neurons or their parts have been considered to be the exclusive cellular sites of these processes, ho...
متن کاملPathobiology of Neurodegeneration: the Role for Astroglia.
The common denominator of neurodegenerative diseases, which mainly affect humans, is the progressive death of neural cells resulting in neurological and cognitive deficits. Astroglial cells are the central elements of the homoeostasis, defence and regeneration of the central nervous system, and their malfunction or reactivity contribute to the pathophysiology of neurodegenerative diseases. Path...
متن کاملFocus on astroglia and neurodevelopment
Radomska, K. 2014. Functional studies of the Quaking gene. Focus on astroglia and neurodevelopment. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1152. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8960-1. The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian...
متن کاملAstroglia and Protein Aggregation Diseases
Many neurodegenerative disorders like Alzheimer’s, Parkinson’s, prion and polyglutamine diseases are caused by gain-of-function mechanisms in which the disease-causing protein accumulates in the form of insoluble protein aggregates or inclusion bodies [1,2]. Whether these aggregated proteins directly cause neurodegeneration is still controversial; however, it is widely believed that soluble for...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2008
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.931604